The mission of the Monoclonal Antibody Core (MAC) is to provide high quality immune reagents, such as novel monoclonal and polyclonal antibodies, that facilitate the research interest s of investigators at Dana-Farber Cancer Institute, Harvard Medical School and affiliated investigators in the community at a reasonable cost. Given the diverse research needs of our clients, the MAC strives to explore and develop new technologies that facilitate the generation of monoclonal antibodies, screening methods, and producing antibodies that are useful for basic research, drug discovery and clinical applications including diagnosis, surrogate markers for disease status, response to therapy or drug toxicity.
The MAC produces high quality antibodies at affordable prices for both academic and corporate facilities.
We are able to accommodate projects from initial planning to completion, including acquiring cDNAs, generation of expression constructs, production of recombinant proteins, acquisition of peptides, immunizations, fusions, hybridoma screening, subcloning, characterization, production and purification of antibodies (with or without conjugation). Additional services including CDR sequencing, stable cell line generation, Fab/F(ab’)2 fragmentation, recombinant protein production, assay development, polyclonal antibody production (with affinity purification) and antibody characterization are also available.
Director of the MAC, Ed has been generating antibodies for over 30 years in both academia and industry. He has expertise in cell culture, animal handling, antibody and immunoassay development. Ed received his Ph.D. from Albany Medical College in 1985, did a post-doc at Harvard Medical School and held positions as a Principal Investigator at the Repligen Corporation and as a Senior Scientist at Millennium Pharmaceuticals.
Scientist, Craig is a specialist at designing immunogens, recombinant protein design, production, purification and conjugation. Prior to joining the MAC, Craig received his PH.D. from the University of Chicago and did his postdoctoral fellowship at Tufts University School of Medicine.
Scientist, Haymanti received her PhD. in Biomedical Sciences from the University of Toledo, College of Medicine (formerly Medical College of Ohio) in the department of Cancer Biology. She came to Dana-Farber Cancer Institute for a post-doctoral position investigating metabolic reprogramming in myeloid leukemia. Haymanti joined the Monoclonal Antibody Core in 2014 as a staff scientist.
Ivan received his Ph.D. in Avian Immunology at Texas A&M University in the department of Poultry Science. The focus of his research has been on antibody generation and immunoassay development. After completing his post-doctoral training at Texas A&M University, Ivan has joined the MAC as a staff scientist.
Lab Assistant Luli immigrated to the United States from Albania, where she had her own engineering company. She brings considerable organizational skills to the Monoclonal Antibody Core.
There are many CROs that make antibodies but making the right antibody is still more an art than science. Experience matters. The MAC has over 40 years of experience making antibodies to draw upon for working with difficult antigens. As a Core facility, our primary goal is to get you a reagent that works for your project’s requirements, not just any antibody that recognizes the antigen. We meet with you and custom design every project to meet your needs, addressing all your questions and concerns. We work with you, combining our expertise with antibodies with your scientific knowledge of what your needs are. We can be flexible in our approach in terms of who does the work to reduce project costs, doing as little or as much as you need us to.